Hanhai New Enzyme has advanced technology and rich experience in mRNA production and LNP preparation. It uses simple, fast, highly stable, and high-quality microfluidic technology to prepare mRNA LNP. It can provide customized services for mRNA and mRNA LNP with different specifications, high yield, high purity, and high cost-effectiveness. LNP with different particle sizes can be customized according to customer needs, and related quality control testing services such as mRNA LNP encapsulation efficiency, particle size, PDI, Zeta potential, etc. can be provided.
Hanhai New Enzyme can provide a one-stop complete solution, allowing customers to customize production from sequence design to LNP preparation, providing customers with satisfactory mRNA raw materials and LNP preparations to the greatest extent possible.
Service category | Project | Duration (working days) | Deliver |
LNP encapsulation | Single package sealing | 5 | LNP and COA |
mRNA synthesis and LNP encapsulation (scientific grade) | 13 | ||
mRNA synthesis and LNP encapsulation (industrial grade) | 13 |
Case 1 | Case 2 | Case 3 | Case 4 | |
RNA name | mRNA 1-LNP | mRNA 2-LNP | saRNA 1-LNP | saRNA 2-LNP |
RNA length | 2547nt | 3018nt | 8076nt | 9865nt |
Preparation mRNA concentration | 135.23 μg/mL | 104.78 μg/mL | 112.38 μg/mL | 120.56 μg/mL |
Entrapment efficiency | 95.2% | 98.7% | 93.2% | 97.8% |
LNP particle size | 88.67 | 90.27 | 93.87 | 99.92 |
Appearance | No impurities/precipitation | No impurities/precipitation | No impurities/precipitation | No impurities/precipitation |
PDI | 0.037  | 0.048  | 0.040  | 0.629  |
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