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The development of mRNA technology has revolutionized modern medicine, particularly in vaccine development and therapeutic applications. However, one of the major challenges is not just the synthesis of high-quality mRNA but also ensuring that it can be safely and efficiently delivered into target cells. Lipid nanoparticles (LNPs) have emerged as the most effective solution for delivering mRNA into cells while maintaining its stability. HZYMES Biotech offers a comprehensive, customizable service that covers the entire mRNA synthesis and delivery process, from sequence design to LNP encapsulation, helping clients achieve their goals more effectively.
At the heart of mRNA production lies in vitro transcription (IVT), the process of transcribing mRNA from a DNA template. IVT is the core of the mRNA preparation process, and its success directly impacts the quality and yield of the final product. HZYMES Biotech offers a robust IVT service, ensuring that the mRNA produced is of high yield, integrity, and efficiency.
To enhance the performance of mRNA, HZYMES provides customized modifications during synthesis, such as the addition of modified nucleosides and cap analogues, which increase the stability of the mRNA and improve translation efficiency in cells.
While the synthesis of mRNA is critical, ensuring its effective delivery into the body presents a significant challenge. mRNA is prone to degradation by enzymes, making it essential to protect it until it reaches its target. The delivery system must also facilitate the entry of mRNA into cells and ensure its release into the cytoplasm before being degraded by lysosomes.
Lipid nanoparticles (LNPs) have become the most efficient delivery system, protecting mRNA from degradation and enhancing its cellular uptake. When compared to other carriers, LNPs provide superior protection, making them the preferred choice for mRNA vaccine and drug delivery.
To support the mRNA synthesis and delivery process, HZYMES provides a comprehensive range of materials and services. These include:
In addition, HZYMES offers custom mRNA and mRNA-LNP synthesis in different specifications, delivering high-yield and high-integrity mRNA solutions that are cost-effective and tailored to client needs.
HZYMES uses an advanced microfluidic technique for the preparation of mRNA-LNPs. This method is not only concise and rapid but also highly scalable, making it ideal for both small-scale and large-scale production. The microfluidic technique allows for the precise control of particle size, ensuring that the resulting LNPs are uniform and stable.
Once the mRNA is synthesized, it is encapsulated in LNPs to protect it from degradation and facilitate its delivery into cells. The encapsulation process ensures that naked mRNA is enveloped in LNPs, which enhances its stability and bioavailability, allowing it to perform its function efficiently once inside the cell.
HZYMES Biotech offers a one-stop complete solution for mRNA and LNP production, providing clients with the flexibility to choose from a range of customizable options. Clients can select specific steps of the process, from sequence design to LNP preparation, depending on their project requirements. This modular approach allows clients to get the required mRNA or LNP stock more quickly and efficiently.
HZYMES' service offerings include:
The following is an outline of HZYMES Biotech’s step-by-step service process:
HZYMES Biotech offers a highly flexible and customizable service for mRNA synthesis and LNP preparation, helping clients overcome the challenges of mRNA delivery and stability. Their advanced microfluidic technology for LNP encapsulation and the use of high-quality materials ensure that mRNA is effectively protected and delivered to target cells, maximizing its therapeutic potential. By providing a one-stop, fully customizable solution, HZYMES allows clients to choose the services they need, helping them accelerate their projects and bring mRNA-based therapies to market faster.
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